after liver transplantation liver transplant May 20, 2022

The increasing number of patients awaiting organ donation has led to an increased need for organ transplantation. Liver transplantation is a complicated medical-surgical procedure opted for end-stage liver failure patients. Acute myopathy may be seen in patients undergone liver transplantation.

The most common CNS headaches are confusion, seizures, posterior leukoencephalopathy syndrome, and the neurotoxic side effects of immunosuppressive capsules, any of which may also require prolonged medical attention or hospitalization.
In addition, neurological headache is a major cause of morbidity and mortality in patients undergoing liver transplantation.

Radiographic examination of seizure patients revealed subcortical parieto-occipital white layer, hypodensities, with cortical involvement within the posterior parietal lobes and significant cortical and white layer involvement within the frontal lobes, parietal, temporal, and occipital.

Acute myopathy is a condition that occurs in critically ill patients with status asthmaticus. High-dose corticosteroids and neuromuscular blockers are mainly given to these patients.

The signs and symptoms of acute myopathy are nonspecific, start unexpectedly, and are prolonged. An acute myopathy has been reported in 7% of liver transplant cases, and the most pathologic location is the selective absence of thick myosin filaments on muscle biopsy. The patient with acute myopathy at the dose examination is treated intraoperatively with intravenous vecuronium and 1 g methylprednisolone.

Acute myopathy is a cause of additional weakness and morbidity in many critically ill patients, including transplant recipients. The electrodiagnostic examination was carried out regularly in the case of necrotizing myopathy. Histopathological examination revealed a necrotizing myopathy with a deficiency of thick myosin filaments.

Patients with myopathy ended up staying in the intensive care unit (ICU) longer than unaffected patients. In summary, severe acute weakness becomes a source of additional morbidity in 7% of patients after orthotopic liver transplantation. The toxic effect of immunosuppressive capsules should be considered a major component of the etiology of neurological headaches.